How long should a FISH test take? Posted on: Aug 11, Aug Posts:
Breast Cancer HER2 Status
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FISH testing | Tests and scans | Cancer Rsearch UK
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. This article has been cited by other articles in PMC. Abstract Diagnostic assays for human epidermal growth factor receptor 2 HER2 expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. Of these women with IBC who underwent surgery, 75 entered the study The HER2 protein is a kDa transmembrane growth factor receptor with tyrosine kinase activity involved in cellular signaling, which regulates cell growth and development 4. HER2 gene amplification or overexpression in breast cancer is a prognostic factor and predictive of a more aggressive clinical course for the patient 5. It is associated with high tumor-grade, hormone receptor-negative tumors, lymph node metastasis 6 , increased risk of recurrence after surgery, poor response to conventional chemotherapy and shortened survival 7 , 8.
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The publisher's final edited version of this article is available at Med Sci Turkey See other articles in PMC that cite the published article. Abstract CerbB2 receptor determination is very important for the prognosis and treatment of breast cancer. Our study compared these two groups in terms of relaps duration.
What Is HER2? HER2 proteins are receptors that are present on some breast cancer cells. Normally, HER2 receptors regulate and control the growth of breast cells, keeping them at a healthy level. However, the HER2 gene is overexpressed in about one in every five cases of breast cancer. This means that instead of having one copy of the gene from each parent, you have multiple HER2 genes.
